Welcome to Micromachinery for Cell Engineering and Physiology
at University of Notre Dame
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We research on diagnosis and therapy in cancer. For diagnosis, we are developing a ultrasound contrast agent. Ultrasound is directly applicable to in vivo imaging due to deep penetration depth. For therapeutic strategies, we are developing a device by integrating a microfluidic chip and ultrasonic transducers to engineer cells, such as T cells, to express specific biomarkers to increase anti-tumor activity. By engineering those cells in vitro, we can reinfuse those engineered cells into a patient’s body to treat cancers. With our research, We hope to improve the quality of life for many people with better cancer treatments and even cures.
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Ultrasound |
Contrast_Imaging |
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Ultrasonic transducers and microfluidic chips to develop integrated device to engineer cells for patient-specific therapy.
Cell Engineering/ Intracellular deliveryUltrasonic transducer will be developed to improve the specificity, efficiency, and throughput of intracellular delivery.
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Early stage cancer detection by using genetically encoded Ultrasound_contrast agents.
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Protein discovery to manipulate cells using ultrasound
Drug delivery using targeted nanomaterials
Our Research are supported by NIH and University of Notre Dame
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Recruitment and Openings
We are hiring Graduate Students with BS or Master degree. The major work will be the development of ultrasound imaging beamforming and next generation imaging technique for cancer detection. Matlab and labview and/or in vivo imaging experience will be a plus.