Welcome to Micromachinery for Cell Engineering and

​Physiology at University of Notre Dame

We research on diagnosis and therapy in cancer. For diagnosis, we are developing a ultrasound contrast agent. Ultrasound is directly applicable to in vivo imaging due to deep penetration depth. For therapeutic strategies, we are developing a device by integrating a microfluidic chip and ultrasonic transducers to engineer cells, such as T cells, to express specific biomarkers to increase anti-tumor activity. By engineering those cells in vitro, we can reinfuse those engineered cells into a patient’s body to treat cancers. With our research, We hope to improve the quality of life for many people with better cancer treatments and even cures.   

Ultrasound

Ultrasonic transducers and microfluidic chips to develop integrated device to engineer cells for patient-specific therapy. ​​

Cell Engineering/ Intracellular delivery

Ultrasonic transducer will be developed to improve the specificity, efficiency, and throughput of intracellular delivery. ​

 Contrast Enhanced Ultrasound (CEUS) Imaging

Early stage cancer detection by using genetically encoded Ultrasound_contrast agents.

Mega GVs

Ana GVs

Protein discovery to manipulate cells using ultrasound
Drug delivery using targeted nanomaterials
Our Research are supported by NIH, NSF, Advanced Diagnostics & Therapeutics, and University of Notre Dame

Recruitment and Opening

We are looking for a PhD graduate student to learn ultrasound imaging. Beamforming algorithms will be developed to improve the quality of ultrasound images. In vivo small animal imaging using Verasonics Vantage system and nanoscale contrast agents will be performed.  

Please send your CV to Prof. Sangpil Yoon (syoon4@nd.edu)