Welcome to Micromachinery for Cell Engineering and

​Physiology at the University of Notre Dame

We research on diagnosis and therapy in cancer. For diagnosis, we are developing a ultrasound contrast agent. Ultrasound is directly applicable to in vivo imaging due to deep penetration depth. For therapeutic strategies, we are developing a device by integrating a microfluidic chip and ultrasonic transducers to engineer cells, such as T cells, to express specific biomarkers to increase anti-tumor activity. By engineering those cells in vitro, we can reinfuse those engineered cells into a patient’s body to treat cancers. With our research, We hope to improve the quality of life for many people with better cancer treatments and even cures.   

Ultrasound

Ultrasonic transducers and microfluidic chips to develop integrated device to engineer cells for patient-specific therapy. ​​

Cell Engineering/ Intracellular delivery

Ultrasonic transducer will be developed to improve the specificity, efficiency, and throughput of intracellular delivery. ​

 Contrast Enhanced Ultrasound (CEUS) Imaging

Early stage cancer detection by using genetically encoded Ultrasound_contrast agents.

Mega GVs

Ana GVs

Protein discovery to manipulate cells using ultrasound
Drug delivery using targeted nanomaterials
Our Research are supported by NIH, NSF, Advanced Diagnostics & Therapeutics, Harper Cancer Research Institute and University of Notre Dame

Join Yoon Lab?

We are looking for PhD graduate students. Yoon lab has wide opportunities in deep learning algorithm development and genetically encoded ultrasound imaging contrast agent development for cancer diagnosis and therapy.  
Please directly email Dr. Yoon if you are interested in joining the Yoon lab. Send your CV and contact information for 3 references. (syoon4@nd.edu)   ​